Oncology and Hematology

Bio-markers of Cancer Stem Cells

Liver cancer is the fifth most analysed and the second most ceaseless reason for cancer death in men around the world. Amongst liver cancers, hepatocellular carcinoma (HCC) represents the major histological subtype and it is one of the most common malignant human tumours. Research into the molecular biology of hepato-carcinogenesis has identified several biomarkers, which could provide additional information in order to better understand the biology of HCC. A large number of biomarkers have been shown to have probable predictive significance and a wide variety of molecular markers have been proven to be excellent diagnostic tools for HCC however it is hard to represent HCC with a single biomarker. Therefore, marks of a mix of biomarkers might be more important for the finding, arranging and visualization of HCC. Specifically, a correlation of HCC-CSCs phenotype to specific hepatic cancer subtypes and to specific clinical and pathological features has not yet been reported in human liver tumours.